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Forum Integrum Consulting - Strona Główna » Pozwolenia zintegrowane

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Establishment of a rat model of chronic Prostatitis/Chronic
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smarty



Dołączył: 10 Paź 2017
Posty: 25

PostWysłany: Wto Paź 10, 2017 06:18    Temat postu: Establishment of a rat model of chronic Prostatitis/Chronic Odpowiedz z cytatem

Establishment of a rat model of chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) induced by immunization with a novel peptide T2.

The exact Prostatitis Treatment etiological mechanism of
Prostatitis/Chronic Prostatitis
is still unclear however autoimmunity Chronic Pelvic Pain Syndrome
is the most valid theory.BPH Treatment We developed a rat model
of Chronic Prostatitis/chronic pelvic pain syndrome Blood In Semen by using a novel
peptide (T2) Blood in Urine
isolated from TRPM8. Burning While Urinating This model might be
beneficial in elucidating mechanisms involved in the pathogenesis of Difficulty Urinating
Chronic Prostatitis/ Pain While Urinating Chronic Pelvic Pain Syndrome (CP/CPPS).

40 male Sprague-Dawley Frequent Urination rats with an average weight of
180-220g were equally distributed into Painful Ejaculation five groups.
The normal control Prostatitis Antibiotics group was injected with
Treatment of Prostatitis normal saline (.9% NACL),
the CFA group with CFA, AL(OH)3 Chronic Prostatitis Symptoms group was given
AL(OH)3 injection Prostatic Hypertrophy,
T2 group using a novel Nonbacterial Prostatitis peptide T2 and T2+AL
(OH)3+CFA group was injected with Causes of Prostatitis T2+AL(OH)3+CFA.
Dosing to all rat groups were Treatment for BPH injected subcutaneously.
Hematoxylin and eosin staining Prostatitis Diet and Immunohistochemistry
were used to investigate inflammatory cell Doxycycline Prostatitis infiltration and
IL-1β in the prostate tissue respectively Prostatectomy.
ELISA technique was used to BPH Symptoms measure the serum
level of CRP and TNF-α. T-test was used to analyze the results.

Maximum infiltration of inflammatory cells and the highest level of IL-1β in the prostate tissue was observed in T2+AL(OH)3+CFA group
as revealed by histopathology and Immunohistochemistry, respectively. Furthermore, T2+AL(OH)3+CFA group attained the peak value of
serum TNF-α and CRP as determined Prostatitis Cure by ELISA technique.

Our results demonstrated that T2 in combination with AL(OH)3 and CFA induced severe Prostatitis in rats.
We believe that our present model will be highly beneficial for investigation of the pathophysiology of
Chronic Prostatitis/Chronic Pelvic Pain Syndrome.

Amoxicillin Prostatitis
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